abstract：:Time-dependent effects of insulin on the leg exchange of glucose, lactate, glycerol, free fatty acids (FFA) and amino acids were measured in relation to oxygen uptake (leg and whole body) and whole body glucose assimilation including oxidation. Seven healthy males (58 +/- 3 years of age) were investigated before opera...

journal_title：European journal of clinical investigation

authors： Lundgren F,Edén E,Arfvidsson B,Lundholm K

更新日期：1991-08-01 00:00:00

abstract：:We recently reported that chloride-depletion metabolic alkalosis (CDMA) results in renal losses of Na, K, and water. In these studies we investigated whether CDMA (induced using a new model that avoids external changes in Na and water balance) was also associated with internal Na and water shifts out of the ECF. CDMA ...

journal_title：European journal of clinical investigation

authors： Garella S,Cohen JJ,Northrup TE

更新日期：1991-06-01 00:00:00

abstract：:We measured the renal haemodynamic and proteinuric response to a meat meal (MM) in ten persistently proteinuric insulin-dependent diabetic patients in a randomized cross-over study of 3 weeks on low protein diet (LPD) or normal protein intake (NPD). On LPD, protein intake (0.64 +/- 0.05 vs 1.15 +/- 0.09 g kg-1 body we...

journal_title：European journal of clinical investigation

authors： Pinto JR,Bending JJ,Dodds RA,Viberti GC

更新日期：1991-04-01 00:00:00

abstract：:In order to study the mechanisms by which nutrients influence post-trauma metabolism, Sprague-Dawley rats received a 25% full-thickness burn and were randomly assigned to receive 12.5 g kg-1 bodyweight (BW) per day amino acids (AA) only, AA and 14.7 g hydrous glucose kg-1 BW per day or AA and 14.7 g hydrous xylitol kg...

journal_title：European journal of clinical investigation

authors： Georgieff M,Pscheidl E,Moldawer LL,Bistrian BR,Blackburn GL

更新日期：1991-04-01 00:00:00

abstract：:Insulin resistance has been reported in normal ageing but discrepancies between such studies may be related to compounding factors such as body composition and exercise patterns. We employed a two-step hyperinsulinaemic euglycaemic clamp to assess peripheral and hepatic tissue insulin sensitivity and glucose recycling...

journal_title：European journal of clinical investigation

authors： Broughton DL,James OW,Alberti KG,Taylor R

更新日期：1991-02-01 00:00:00

abstract：:A significant rise in serum concentrations of aluminum was demonstrated in 23 patients prophylactically treated with the antacid magaldrate, whereas no increase in serum aluminium was observed in another 26 critically ill patients, in whom the use of antacids was avoided. In parallel, urinary excretion rates of alumin...

journal_title：European journal of clinical investigation

authors： Ittel TH,Gladziwa U,Mück W,Sieberth HG

更新日期：1991-02-01 00:00:00

abstract：:Thirty-one patients with IgG antibodies to cardiolipin (ACLA) were studied to determine their in vivo formation of the platelet aggregating and vasoconstricting substance thromboxane A2 (TxA2) and the platelet inhibiting and vasodilating substance prostacyclin (PGI2). This was done by measurements in urine of their en...

journal_title：European journal of clinical investigation

authors： Arfors L,Vesterqvist O,Johnsson H,Gréen K

更新日期：1990-12-01 00:00:00

abstract：:Endothelin-1 is a recently described endothelium-derived vasoconstricting peptide. Plasma concentrations of immunoreactive (IR-) endothelin were investigated in six healthy young men applying a radioimmunoassay after extraction of endothelin from plasma. In venous plasma a mean concentration of 1.3 +/- 0.4 pmol l-1 wa...

journal_title：European journal of clinical investigation

authors： Wagner OF,Nowotny P,Vierhapper H,Waldhäusl W

更新日期：1990-10-01 00:00:00

abstract：:The effects of glucose on the cytoplasmic Ca2+ concentration (Ca2+i) regulating insulin release were investigated using pancreatic beta-cells representative for the normal and diabetic situations. Increase of the glucose concentration resulted in a slight lowering of Ca2+i followed by a rise, often manifested as high ...

journal_title：European journal of clinical investigation

authors： Hellman B,Berne C,Grapengiesser E,Grill V,Gylfe E,Lund PE

更新日期：1990-10-01 00:00:00

abstract：:Novel, powerful and long-acting inhibitors of gastric acid secretion include second generation H2-blockers and so-called proton pump inhibitors, such as omeprazole. Gastric carcinoids were found to develop in experimental animals as a consequence of continuous long-term administration of several of these highly effect...

journal_title：European journal of clinical investigation

authors： Håkanson R,Sundler F

更新日期：1990-10-01 00:00:00

abstract：:To examine the possible effects of hyperoxalaemia on anaerobic metabolism and erythrocyte pyruvate kinase activity, we induced a rise in plasma oxalate in 11 dialysis patients by the oral administration of ascorbic acid, 500 mg day-1 for 3 weeks. Blood samples were taken from the same antecubital vein before and after...

journal_title：European journal of clinical investigation

authors： Tomson CR,Channon SM,Ward MK,Laker MF

更新日期：1990-08-01 00:00:00

abstract：:A continuous intravenous infusion of L-leucine (300 mumols min-1) was given to 12 healthy females over a 2 1/2 h period. Arterial plasma concentrations of amino acids and the keto acids of the branched-chain amino acids (BCAA) were measured. In six subjects muscle biopsies were taken before and at the end of the infus...

journal_title：European journal of clinical investigation

authors： Alvestrand A,Hagenfeldt L,Merli M,Oureshi A,Eriksson LS

更新日期：1990-06-01 00:00:00

abstract：:Currently available information on adipose tissue metabolism in man is mainly based on studies in vitro. In the present work adipose tissue lipid uptake was studied in vivo in man. 100 g glucose and 120 g milk fat with 10 microCi U-14C oleic acid were given in the overnight fasting state to eight women and 2 h after a...

journal_title：European journal of clinical investigation

authors： Mårin P,Rebuffé-Scrive M,Björntorp P

更新日期：1990-04-01 00:00:00

abstract：:In controls and in patients suffering from congestive heart failure (CHF) the circulating levels of catecholamines, neuropeptide Y-like immunoreactivity (NPY-LI), vasoactive intestinal peptide-LI (VIP-LI), substance P-LI (SP-LI) and calcitonin generated peptide-LI (CGRP-LI) markers of sympathetic, parasympathetic and ...

journal_title：European journal of clinical investigation

authors： Edvinsson L,Ekman R,Hedner P,Valdemarsson S

更新日期：1990-02-01 00:00:00

abstract：:The degradation of vasoactive intestinal peptide (VIP) was studied using an isolated perfused rat lung model. 125iodine labelled VIP (125I-VIP) was used as a tracer. VIP was cleared from the perfusate by a single lung passage up to concentrations of 1 nmol l-1. The clearance rate was decreased at higher concentrations...

journal_title：European journal of clinical investigation

authors： Bernhard W,Bothe-Sandtfort E,Koop H,Cassel W,Von Wichert P

更新日期：1989-12-01 00:00:00

abstract：:Ten men with Klinefelter's syndrome were studied to assess the effect of testosterone replacement on plasma lipids and apolipoproteins. Measurements taken before the insertion of a testosterone ester implant were compared with those obtained 1 week and 4 weeks later. Mean plasma testosterone, androstenedione, total ch...

journal_title：European journal of clinical investigation

authors： Jones DB,Higgins B,Billet JS,Price WH,Edwards CR,Beastall GH,Shepherd J,Sweeting VM,Horn DB,Wenham PR

更新日期：1989-10-01 00:00:00

abstract：:Pepsinogen A (PGA) and pepsinogen C (PGC) are negatively charged, low molecular weight (LMW) proteins with a striking difference in renal handling: PGA (molecular weight 43,500 daltons) shows a high fractional excretion while the fractional excretion of PGC (molecular weight 40,500 daltons) is low, presumably due to t...

journal_title：European journal of clinical investigation

authors： ten Kate RW,Pals G,Res JC,van Kamp GJ,Verheugt FW,Pronk JC,Donker AJ,Eriksson AW,Meuwissen SG

更新日期：1989-06-01 00:00:00

abstract：:We have examined resting and thrombin (0.3 units ml-1) induced release of noradrenaline by washed platelets from 15 normal subjects and eight patients with heterozygous familial hypercholesterolaemia. Platelets from both normal and hypercholesterolaemic subjects showed irreversible aggregation with 0.3 units ml-1 thro...

journal_title：European journal of clinical investigation

authors： Smith CC,Wilson AP,Prichard BN,Betteridge DJ

更新日期：1989-06-01 00:00:00

abstract：:To understand better impairment of glucose utilization in diabetics during a hyperosmolal state, in vitro models were established to evaluate the effects of hyperosmolality on basal glucose uptake as well as glucagon dependent glucose release by isolated hepatocytes. In these studies simulating a hyperglycaemic (40 mm...

journal_title：European journal of clinical investigation

authors： Komjati M,Kastner G,Waldhäusl W,Bratusch-Marrain P

更新日期：1989-04-01 00:00:00

abstract：:The effects of percutaneous electrical stimulation (70 V, 300 microseconds pulses at 30 Hz) on muscle composition and rate of protein synthesis were studied in seven patients with quadriceps atrophy secondary to unilateral osteoarthritis of the knee (stimulated group). Quadriceps were stimulated on the affected side f...

journal_title：European journal of clinical investigation

authors： Gibson JN,Morrison WL,Scrimgeour CM,Smith K,Stoward PJ,Rennie MJ

更新日期：1989-04-01 00:00:00

abstract：:The aim of the present study was to investigate antral endocrine cell populations and tissue and circulating hormone levels following a 4-week oral regimen with prostaglandin E2 (25, 250 and 5000 micrograms/kg-1 b.i.d.) or a stable methyl analogue (5 and 50 micrograms kg-1 b.i.d.). Epithelial hyperplasia of the gastri...

journal_title：European journal of clinical investigation

authors： Uribe A,Grimelius L,Theodorsson LE,Riis-Angelo L,Johansson C

更新日期：1989-04-01 00:00:00

abstract：:In the present study, the hypothesis that the affinity of LDL to arterial proteoglycans might discriminate myocardial infarction patients from controls were tested. The patients were 52 men who had sustained a myocardial infarction at an age of 50 years or less and the controls, selected from a random population sampl...

journal_title：European journal of clinical investigation

authors： Linden T,Bondjers G,Camejo G,Bergstrand R,Wilhelmsen L,Wiklund O

更新日期：1989-02-01 00:00:00

abstract：:Lymphocytes were used as a cellular model for the in vitro measurements of maximal ouabain binding sites in order to assess any changes in young men at increased risk of developing essential hypertension, and to analyse whether any such changes were associated to borderline hypertension and/or heredity. Four groups we...

journal_title：European journal of clinical investigation

authors： Nielsen JR,Pedersen KE,Klitgaard NA,Johansen T

更新日期：1989-02-01 00:00:00

abstract：:Investigations were carried out to analyse the interactions of alpha 2-antagonists (yohimbine, idazoxan, SK & F-86,466) with human fat cell alpha 2-adrenoceptors. All the alpha 2-antagonists enhanced the lipolytic potencies of epinephrine with an order of potency: yohimbine greater than idazoxan greater than SK & F-86...

journal_title：European journal of clinical investigation

authors： Galitzky J,Taouis M,Berlan M,Rivière D,Garrigues M,Lafontan M

更新日期：1988-12-01 00:00:00

abstract：:The ratio at steady-state of alpha-ketoisocaproic acid (KIC) to leucine 13C enrichments in plasma during continuous infusion of [13C]leucine was examined in 58 studies under a variety of conditions. The ratio was lower (P less than 0.001) in 'arterialized' venous plasma (mean +/- SD 0.85 +/- 0.09) than in deep venous ...

journal_title：European journal of clinical investigation

authors： Thompson GN,Pacy PJ,Ford GC,Merritt H,Halliday D

更新日期：1988-12-01 00:00:00

abstract：:Skeletal muscle glycogen deposition, and the activation of muscle glycogen synthase and pyruvate dehydrogenase during a hyerinsulinaemic euglycaemic clamp have been measured in six young and six elderly males matched for body mass index, physical activity and diet. Clamp glucose requirement (insulin, 0.1 U kg-1 h-1) w...

journal_title：European journal of clinical investigation

authors： Kruszynska YT,Petranyi G,Alberti KG

更新日期：1988-10-01 00:00:00

abstract：:The serum concentrations of collagen type IV,7S, collagen type IV,nc1, and aminoterminal type III procollagen peptide immunoreactive components were measured by means of specific radioimmunoassays during development of granulation tissue in rats. The results were compared with tissue deposition of basement membranes a...

journal_title：European journal of clinical investigation

authors： Hørslev-Petersen K,Pedersen LR,Bentsen KD,Brocks D,Garbarsch C,Kim KY,Hahn EG,Schuppan D,Lorenzen I

更新日期：1988-08-01 00:00:00

abstract：:Assuming that lithium is exclusively reabsorbed in the proximal tubules pari passu with sodium (Na), the lithium clearance (CLi) has been advanced as an index of filtrate delivery from the proximal tubules. In order to determine whether water loads in a range commonly given during clearance studies affect CLi, we stud...

journal_title：European journal of clinical investigation

authors： Boer WH,Koomans HA,Dorhout Mees EJ

更新日期：1988-06-01 00:00:00

abstract：:The permeability of the gastrointestinal tract was investigated by means of polyethylene glycol (PEG), given orally. The PEG solutions contained oligomers with molecular weights from 414 to 1206. The urinary recovery of ingested PEG was determined by high performance liquid chromatography (HPLC). Considerable inter- a...

journal_title：European journal of clinical investigation

authors： Philipsen EK,Batsberg W,Christensen AB

更新日期：1988-04-01 00:00:00

abstract：:beta-Adrenoceptor binding on peripheral blood mononuclear cells (PBMC) of healthy adult volunteers was investigated using the radioligand 125iodo-cyanopindolol (ICYP). Saturation binding studies were performed with nine different concentrations of ICYP. Receptor density and affinity were calculated by Scatchard plots....

journal_title：European journal of clinical investigation

authors： Griese M,Körholz U,Körholz D,Seeger K,Wahn V,Reinhardt D

更新日期：1988-04-01 00:00:00

abstract：:Synthetic stable analogues of thromboxane A2 (TXA2), cyclic endoperoxides (PGH2) and prostacyclin (PGI2) opened up new opportunities for investigating the mechanisms of action of these compounds. They proved to be useful pharmacological probes for characterizing PGI2 and TXA2/PGH2 receptors. Over the past few years, n...

journal_title：European journal of clinical investigation

authors： Jaschonek K,Muller CP

更新日期：1988-02-01 00:00:00

abstract：:Secondary bile acids have been implicated in colonic carcinogenesis. Transformation of primary into secondary bile acids (7 alpha-dehydroxylation) in the large bowel is a pH-dependent process. Inhibition of this reaction could be achieved by lowering colonic pH. We, therefore, studied the effects of lactulose (a non-a...

journal_title：European journal of clinical investigation

authors： Nagengast FM,Hectors MP,Buys WA,van Tongeren JH

更新日期：1988-02-01 00:00:00

abstract：:Metabolic alterations related to resting energy expenditure (REE) and fat metabolism have been noted during sepsis, and often depend on the causative agent and the stage and severity of the illness. We studied the effect of IL-1, the protein mediator of the 'acute phase' response during infection, on REE, respiratory ...

journal_title：European journal of clinical investigation

authors： Tocco-Bradley R,Georgieff M,Jones CT,Moldawer LL,Dinarello CA,Blackburn GL,Bistrian BR

更新日期：1987-12-01 00:00:00

abstract：:The cellular mechanisms controlling adaptive intestinal mucosal hypo- and hyperplasia are poorly understood but changes in tissue polyamine levels and in the activity of the key enzymes controlling their synthesis (ornithine decarboxylase: ODC) and degradation (diamine oxidase: DAO) have been implicated. Therefore, in...

journal_title：European journal of clinical investigation

authors： Hosomi M,Stace NH,Lirussi F,Smith SM,Murphy GM,Dowling RH

更新日期：1987-10-01 00:00:00

abstract：:Bradykinin infusion has been shown to improve glucose metabolism in non-insulin-dependent diabetic subjects (NIDD). Therefore, we tested the following hypothesis: inhibition of Kininase II, the bradykinin (BK) degrading enzyme, by captopril may also improve glucose metabolism in NIDD. Immediate effects of captopril on...

journal_title：European journal of clinical investigation

authors： Jauch KW,Hartl W,Guenther B,Wicklmayr M,Rett K,Dietze G

更新日期：1987-10-01 00:00:00

abstract：:Serum lactic dehydrogenase (S-LDH) was analysed at diagnosis in ninety-three patients with multiple myeloma. The patients were then followed up after a mean observation period of 39 months (SD 29). Serum lactic dehydrogenase was elevated in twenty-seven out of ninety-three patients and found to correlate with the seru...

journal_title：European journal of clinical investigation

authors： Simonsson B,Brenning G,Källander C,Ahre A

更新日期：1987-08-01 00:00:00

abstract：:The formation of metabolites of arachidonic acid by the cyclo-oxygenase and lipoxygenase pathways were determined in human lung tissue, obtained from surgery. In this measurement the chopped tissue was incubated with the calcium ionophore A23187. Formation of metabolites from [1-14C] arachidonic acid was also determin...

journal_title：European journal of clinical investigation

authors： Zijlstra FJ,Naaktgeboren M,Mons H,Vincent JE

更新日期：1987-08-01 00:00:00

abstract：:Two cases of congenital defect in iodide trapping mechanism are related. The absence of thyroid and gastric concentration of 99mTcO4 led to the diagnosis. The study of saliva and gastric:serum concentration ratios confirmed the complete defect. The kinetics of radioiodine studied by external detection showed an early ...

journal_title：European journal of clinical investigation

authors： Leger FA,Doumith R,Courpotin C,Helal OB,Davous N,Aurengo A,Savoie JC

更新日期：1987-06-01 00:00:00

abstract：:Quinidine is known to reduce the renal clearance of digoxin, but this effect does not completely explain the influence of quinidine on the total clearance of digoxin. We therefore studied the effect of quinidine administration on biliary clearance of digoxin in five patients with atrial fibrillation. Biliary clearance...

journal_title：European journal of clinical investigation

authors： Angelin B,Arvidsson A,Dahlqvist R,Hedman A,Schenck-Gustafsson K

更新日期：1987-06-01 00:00:00

abstract：:Thyroid hormones occasionally appear less effective when administered alone to patients with panhypopituitarism, and manifestations suggestive of hypothyroidism have been reported in patients suffering from untreated Addison's disease. In the latter condition, thyrotropin secretion is increased: this occurs already af...

journal_title：European journal of clinical investigation

authors： De Nayer P,Dozin B,Vandeput Y,Bottazzo FC,Crabbe J

更新日期：1987-04-01 00:00:00